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In the first apparition the healing that followed was spiritual that of conversion from barbarism to the blessed Catholicism; in the second, physical cures as well as conversions.
But the significance of the titles she gave includes the close connection between two apparitions that were 327 years apart. In both Mary's Motherhood is proclaimed. At Guadalupe she came as "Mother", Mother of the poor, the Mother of Sorrows and the Mother of God, as depicted in her garments which to the Indian natives of Mexico were evidence of her approaching time at Bethlehem. At Lourdes, Mary's Divine maternity is enshrined in her Immaculate Conception, God's great work and miracle, the Mother of God and of the Church, who was conceived without Original Sin, who bears the Savior of Mankind. The name Guadalupe, is roughly translated as the "savior from the devil." In truth both apparitions are Apocalyptic, for Our Lady is the Woman with the Twelve Stars who will crush the seed of satan.
Memorare to our Lady of Guadalupe
Remember, O most gracious Virgin Mary of Guadalupe, that in thy celestial apparitions on the mount of Tepeyac, thou didst promise to show thy compassion and pity towards all who, loving and trusting thee, seek thy help and call upon thee in their necessities and afflictions.
Thou didst promise to hearken to our supplications, to dry our tears and to give us consolation and relief. Never was it known that anyone who fled to thy protection, implored thy help, or sought thy intercession, either for the common welfare, or in personal anxieties, was left unaided.
Inspired with this confidence, we fly unto thee, O Mary, ever Virgin Mother of the True God! Though grieving under the weight of our sins, we come to prostrate ourselves in thy august presence, certain that thou wilt deign to fulfill thy merciful promises. We are full of hope that, standing beneath thy shadow and protection, nothing will trouble or afflict us, nor need we fear illness, or misfortune, or any other sorrow.
Thou hast decided to remain with us through thy admirable image, thou who art our Mother, our health and our life. Placing ourselves beneath thy maternal gaze and having recourse to thee in all our necessities we need do nothing more. O Holy Mother of God, despise not our petitions, but in thy mercy hear and answer us.
[Here mention your petition.]
Five Hail Marys. . . in gratitude for the four apparitions to Juan Diego and the one to Juan Bernardino